The world of medical science is constantly evolving. New discoveries, innovations, and clinical research strengthen the foundation of modern healthcare. Medical journals are the most reliable means of disseminating research findings in this field to the world. They not only provide scientists and doctors with the latest information but also guide health policies and clinical guidelines.
Thousands of medical journals are published today, but a few stand out for their credibility, influence, and historical contributions. The 10 journals recognized as the most prestigious in 2025 hold a special place in the medical world due to their rigorous editorial standards, high-quality research, and global influence.
1. The New England Journal of Medicine (NEJM)
Impact Factor: 91.245
NEJM is considered the world’s most influential medical journal. Established in 1812, the journal was initially limited to the Boston area, but over time, it gained global recognition. Initial reports of landmark discoveries such as penicillin and chemotherapy were published in this journal.
Its most significant feature is that it only publishes research that has the potential to change medical practices and guidelines. Its selection criteria are extremely strict, and only 5% of research papers are selected for publication. This is why it is the preferred choice of physicians and researchers worldwide.
2. The Lancet
Impact Factor: 79.321
Founded in 1823 by surgeon Thomas Wakley, The Lancet has always championed medical and public health reform. This journal influences not only scientific research but also health policies. From tobacco control to global pandemics, The Lancet’s reports have time and again shaped the medical world.
Its editorial standards are extremely strict, and less than 10% of research is accepted. Priority is given to papers with a global perspective and impact on health policies.
3. Journal of the American Medical Association (JAMA)
Impact Factor: 56.272
Founded in 1883, JAMA is one of the most widely read medical journals not only in the United States but throughout the world. Its mission was to unite the voices of doctors and researchers. Over time, it has made significant contributions to clinical research and health policy.
This journal publishes original clinical research, meta-analyses, and systematic reviews. With an acceptance rate of approximately 8%, it only accepts studies that have the potential to change medical guidelines.
4. Nature Medicine
Impact Factor: 53,440
Launched in 1995, Nature Medicine is a leading platform for translational and biomedical research. Its unique focus is its ability to connect basic scientific discoveries with clinical treatments.
This journal prioritizes research that has a direct impact on disease prevention and treatment methods. Only 7% of research papers are accepted, and a rigorous peer-review process makes it even more credible.
5. British Medical Journal (BMJ)
Impact Factor: 39.890
Founded in 1840, the BMJ has always promoted evidence-based medicine. The journal is considered a champion of independence and transparency.
The BMJ was the first major journal to adopt open peer review. Its aim was to make research more transparent and accountable. Only 4-7% of papers are accepted, and these are studies that have an impact on public health policies.
6. Annals of Internal Medicine
Impact Factor: 25.391
Founded in 1927, this journal specializes exclusively in internal medicine. Its research on chronic diseases, cardiology, oncology, and infectious diseases is recognized globally.
With an acceptance rate of approximately 10%, this journal values ​​studies that can provide practical solutions to clinicians.
7. Journal of Clinical Investigation (JCI)
Impact Factor: 14.808
Founded in 1924, JCI is a bridge between basic science and clinical medicine. This journal publishes research specifically focused on immunology, oncology, and metabolic diseases.
Only about 12% of research is considered eligible for publication, and only those that have a direct impact on patient care are selected.
8. PLOS Medicine
Impact Factor: 11.675
Founded in 2004, this journal revolutionized open access. Its goal was to make scientific research accessible to everyone.
PLOS Medicine specifically publishes studies related to global health, epidemiology, and public health. Its transparent review system and global approach have earned it a unique position in the field of medical research.
9. Journal of the American College of Cardiology (JACC)
ImImpact Factor: 24.094
Established in 1983, JACC is the leading source of research on cardiovascular diseases. It is highly trusted for new discoveries, clinical trials, and treatment studies in cardiology.
Only 10% of research papers are accepted here, and these are studies that could change the direction of heart disease treatment.
10. Circulation
Impact Factor: 39.918
Circulation, launched by the American Heart Association in 1950, is the leading journal for heart and stroke research. Studies published in it often influence clinical guidelines and treatment methods.
With an acceptance rate of 9%, this journal prioritizes only studies that have the potential to improve patients’ lives.
Conclusion
These top 10 medical journals of 2025 are not only guides for researchers and clinicians, but they also influence global health policies and medical practices. Their hallmark is that they only publish research that is original, based on rigorous scientific methods, and has global impact.
It is an honor for any researcher to be published in these journals, as it signifies that their work is not only scientifically valid but also has the potential to change the direction of healthcare.
